There are many debates on specific causes of Multiple Sclerosis. However, in the absence of conclusive evidence, medical scientists can only speculate on the causes and risk factors behind Multiple Sclerosis and other related autoimmune diseases. Although some theories on a number of Multiple Sclerosis specific triggers were partially confirmed by recent medical studies, doctors need additional data in order to identify the exact set of causes.
Global epidemiology of Multiple Sclerosis has led neuro scientists to suspect possible interaction of genetic and environmental factors. It seems that these factors determine initiation of an autoimmune response that leads to destruction of the myelin layers. Several scientific studies suggest a genetic trigger for Multiple Sclerosis. First, Multiple Sclerosis is rare among Oriental populations regardless of where they live. Today there are strong arguments for the existence of genetic factors in Multiple Sclerosis susceptibility. Must be undoubtedly factors related to sex, as females are most affected by disease, illness gender ratio is 2 to 1.
Independent of sex, the relative risk of an individual Multiple Sclerosis degree relative with the disease reached is 20 to 50 times higher than the general population. Twin studies show that simultaneous achievement is more common in monozygotic (20-35%) than dizygotic (2-20%). Genetic factors intervention compared to the existence of a predisposition immune-patic defining susceptibility to Multiple Sclerosis. Unlike other hereditary diseases in which only one gene is abnormal, in Multiple Sclerosis is likely that multiple genes need to be affected, because one of them trigger the disease.
Manifestations of Multiple Sclerosis vary from person to person, depending on which area of the brain or spinal cord is affected. Loss of myelin damage caused by multiple sclerosis can affect any region of the central nervous system. Symptoms can appear and disappear or become more or less severe from day to day or, more rarely, from hour to hour. Symptoms may become more severe with increasing (or in rare cases with decreased) body's temperature or after a viral infection.
